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Born Marlene Aloisio in Detroit, Michigan, Willoughby chose the surname "Willoughby" for her professional work after someone called her "willowy" due to her lithe, 5'-10" frame. She followed her older sister, Jacqueline Carol, in pursuing a career in show business. In 1969, she appeared in the controversial Lennox Raphael Off-Off-Broadway play Che! Other theater roles followed including the Obie Award winning Dracula Sabbat, Fuck Mother and Keepers of the Hippo Horn. She also landed parts in mainstream fare such as No Place to Hide (1970), Up the Sandbox (1972), I, the Jury (1982) and Trading Places (1983), and softcore work such as Voices of Desire (1972) and While the Cat's Away... (1972). Following her retirement from porn, she also appeared in the mainstream film Married to the Mob (1988). Willoughby began making hardcore porn in 1975. Her notable appearances include The Opening of Misty Beethoven (1976), The Farmer's Daughters (1976), Outlaw Ladies (1981), and Foxtrot (1982). She appeared in many Pornographic magazines, most notably Penthouse and also wrote columns for such magazines as High Society and Velvet. She also arranged film release parties and toured as a Burlesque dancer. During her career in porn, Willoughby was known as an activist speaking out in favor of the porn industry.

This Ain't The Artist XXX
Merle Michaels Anal Strawberry

Sick & Nasty Classic Porn Previews
as (archive)

Nurse My Cock
as (archive footage)

Big Tit Superstars of the 80's: Bridgette Monet Collection

Swedish Erotica 7
as (archive footage)

Seriously... Phil Collins
as Redheaded Fan

Legends of Porn II
as (archive footage)

Married to the Mob
as Mrs. 'Fat Man'
Babes in Joyland
as Girl Dancing Nude (segment "Milk and Honey") (archive footage)
Deep Voyage

Lustfire
as Vanity

Magic Girls
as Marlene (archive footage)

Trading Places
as Woman Passed Out on Couch (uncredited)

Oriental Techniques in Pain and Pleasure
as Audience Member (uncredited)

Hot Dreams
as Ellen Van Zandt

Glitter
as Abby Benson

Foxtrot
as Zelda

I, the Jury
as Orgy Participant (uncredited)

Angel in Distress
as Mrs. Susan James

Mistress Electra
as Natasha

Nasty Nurses

Pandora's Mirror
as Veronica Barrett

The Tiffany Minx
as Anne

Outlaw Ladies
as Cassie Lacey

Dracula Exotica
as Medieval Partygoer

Fascination
as Sheila

Girls U.S.A.
as Auditioning Hooker

The Best of Porno
as (archive footage)

Unnatural Family

N.Y. Babes
as Baldie Boyer

More Than Sisters
as Matron MacNamara

Sunny
as Mrs. Carter / Mother

A Girl Like That
as Jolly's Fellow Hooker

The Pink Ladies
as Hooker / Orange Workout Girl

Fulfilling Young Cups
as Erica Feinberg

Auto-Erotic Practices

People

Fiona on Fire
as Camille Forneau

Beach House
as (archive footage)

The Fur Trap
as Jeannie

From Holly with Love
as Eileen Hanley (uncredited)

Dirty Lily
as Al's Girlfriend

That Burning Sensation
as Girl with Bag Fetish

Painful Desires
as Caterine Castrati (uncredited)

A Taste of Bette
as Terry

Prized Possession
as Jill (uncredited)

The Last Sex Act

Intimate Desires
as Susan Berg

Candy Lips
as The Ladies

Raw Footage
as Betty

Inside Jennifer Welles
as Lesbian Professor

The Night Bird
as Sex Performer in Purple (uncredited)

Betrayed Teens
as Helen Dunraven

The Trouble with Young Stuff
as Rose Volare

The New York City Woman
as Nurse Brandt

Intimidation
as Paula

A Woman's Torment
as Fannie Grudkow

Honeymoon Haven
as Francine Jackson

The Passion Seekers
as Debbie