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Acting
Sirena grew up around the U.S. and abroad her mother, Margaret Irwin-Brandon, is a harpsichordist and conductor of a Baroque Orchestra, and her father, John Irwin, was a physicist (with a significant stint as a dropped out hippie)-landed ultimately at Sanford University. After time spent at Northfield Mt. Hermon boarding school where she fell in love with theater, she attended San Francisco State University and graduated with degrees in Theater and International Relations. After a successful stint in a popular San Francisco sketch comedy group, she landed in Los Angeles where her knack for voices and accents were quickly put to use in the world of animation. This ultimately brought her to her successful career as a voice director in animation (thanks to her mentor Andrea Romano!) garnering her an Emmy nomination in 2021.

SpongeBob and Patrick's Timeline Twist-Up
as Pffht / Various Incidental Characters (voice)

SpongeBob Squarepants: Kreepaway Kamp
as Lady Upturn / Nurse Helga / Mo / Teen Girls (voice)
A Man Alone
as Therapist

We Baby Bears
as Guard #1 / Old Lady Bug / Poochy (voice)

The Patrick Star Show
as Go Girl / Go Woman (voice)

Kamp Koral: SpongeBob's Under Years
as SpongeBob's Mom / Mowhak Girl / Campers (voice)

The Mighty Ones
as The Queen (voice)

SpongeBob’s Big Birthday Blowout
as SpongeBob’s Mom / Gawky Female / The Kid / Office Worker

Apple & Onion
as The Eater (voice)

Batman vs. Two-Face
as Harleen Quinzel (voice)

Batman: Return of the Caped Crusaders
as Miranda Moore (voice)

SpongeBob LongPants
as Fancy Lady Fish / Kid Fish (voice)

The SpongeBob Movie: Sponge Out of Water
as Computer Voice / Shocked Mob Member (voice)

Justice League: Throne of Atlantis
as Queen Atlanna (voice)

Vitaminamulch: Air Spectacular
as Additional Voice

Planes
as Additional Voices (voice)

Superman: Unbound
as Alura (voice)
The Longer Day of Happiness
as Alisa

Spongebob’s Runaway Roadtrip
as Margret SquarePants

Can I Be Your Bratwurst, Please?

Batman: The Brave and the Bold
as Mera (voice)

Electric Apricot
as The Photographer

Holly Hobbie and Friends: Christmas Wishes
as Mrs. Palmer (voice)

So NoTORIous
as Cheryl - Tori's Publicist

The SpongeBob SquarePants Movie
as Reporter / Driver / Ice Cream Lady (voice)

Entourage
as Frida

Spongebob Squarepants: Christmas
as Woman Fish

Stripperella
as Persephone (voice)

The Trip
as Beverly

The Sky is Falling
as Gabby

SpongeBob SquarePants
as Margaret SquarePants (voice)

The Drew Carey Show
as Raven

Ellen
as Cherry-O