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Joanna Firestone was born in 1986 to Jewish parents Fred and Marilyn Firestone. Growing up as teenager, Jo would have cake baking competition with her friends including renowned pastry chef Claire Saffitz. She once won the competition with Box St. Louis butter vs. Claire’s $50 chocolate cake She has a brother, Ben Firestone, who works in commercial real estate. She grew up in Clayton, Missouri, a suburb of St. Louis. She graduated from Clayton High School and later Wesleyan University in Connecticut, with a degree in theatre.

Never Change!
as Amelia Nadler

Win or Lose
as Sweaty (voice)

The Singles Retreat
as Concierge 1

Fired on Mars

Gold and Mud

Matt Rogers: Have You Heard of Christmas?
as Katie (Agent)

Aqua Teen Forever: Plantasm
as Felicity in IT (Voice)

Cicada
as Tracy

Good Timing with Jo Firestone
as Self

Teenage Euthanasia
as Euthanasia 'Annie' Fantasy (voice)

Together Together
as Tamara

The Great North
as Greta Meatweep (voice)

Rate the Cookie
as Self

Dessert Person with Claire Saffitz
as Self

Save Yourselves!
as Desi

To the Moon
as Mom

What We Do in the Shadows
as Jo

Vanilla
as Samantha

Summer Camp Island
as Mallory (voice)

Joe Pera Talks With You
as Sarah Conner

The Hawkins Family Yule Log
as Grandma

Observatory Blues
Jo Firestone: Comedy Central Stand-up Presents
as Self
How Many Farts Measure a Life?
as Resident Angel

Comedy Central Stand-Up Presents
as Self
Joe’s Pub Presents: A Holiday Special

Search Party
as Carla

Don't Think Twice
as Jo
Thingstarter

Boy Band
as Sandra

The Tonight Show Starring Jimmy Fallon
as Self - Guest

Broad City
as 42 Squirts employee